Bio

Research interests:

Publications

1. Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design, 2021, European Journal of Medicinal Chemistry 226, 113819

2. Design, synthesis and bioevaluation of novel 6-substituted aminoindazole derivatives as anticancer agents, 2020, RSC Advances 10 (73), 45199-45206

3. In vitro and in silico determination of glutaminyl cyclase inhibitors, 2019, RSC Advances, 9, 29619-29627

4. Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer’s Agents by Structure-Based Design, 2019, J. Med. Chem, 62, 8011-8027

5. Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents, 2019, Bioorg. Med. Chem, 27, 1370-1381

6. C-terminal HSP90 inhibitor L80 elicts anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition, 2019, Cancer Lett., 447, 141-153

7. Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors, 2018, Bioorg. Med. Chem., 26, 3133-314

8. Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer’s agents: Structure-activity relationship study of Arg-mimetic region, 2018, Bioorg. Med. Chem., 26, 1035-1049

9. Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer Agents Based on Rational Design, 2017, J. Med. Chem., 60, 2573-2590

10. Inhibition of Glutaminyl Cyclase Ameliorates Amyloid Pathology in an Animal Model of Alzheimer’s Disease via the Modulation of µ-Secretase Activity, 2015, Journal of Alzheimer’s Disease, 43, 797–807

11. α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists, 2015, Bioorg. Med. Chem. Lett., 25, 2326-2330

12. 2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists, 2014, Bioorg. Med. Chem. Lett., 24, 4044-4047

13. α -Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists, 2014, Bioorg. Med. Chem. Lett., 24, 2685-2688

14. TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides, 2013, Bioorg. Med. Chem., 21, 6657-6664

15. Structure–activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template, 2013, Bioorg. Med. Chem., 21, 3821-3830

16. Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents

2011, Bioorg. Med. Chem. Lett., 21, 7509-7512